Christian
Tyler is correct - if you have the tune or Bluetooth version of 123ignition, you can use the side “vacuum all the time “ port but if you have the pre-programmed 123 and are using program E, it usually does exactly what you are experiencing. Program E expects all emissions equipment to work and the two way valve to control vacuum.
If you are using program 8 you need to have vacuum coming from below the throttle body like a euro 280 or any 250.
Also once vacuum is correct you would time the car so at idle you are few degrees BTDC since you are not using any emissions equipment.
Are you using side vacuum port or have you modified to have the port under the throttle body available?
Thanks, very helpful.

I am still using the US throttle house with the constant vacuum side-port, and I found that using program 8 was the best compromise. I also tried program E, but found it even worse with the configuration I currently have!
But I have (over the winter) found a euro throttle house on Ebay, which I am currently restoring, but I also here see light around the throttle plate, when the throttle plate is closed, so I would also like to find a new plate for this house as well. Actually, when comparing the US and Euro throttle houses, they are actually physically identical, and both have both vacuum ports. However, on the US one, the (euro) port below the throttle house is blinded off, but I think there is still a vacuum channel, as i can see the small hole just next to the throttle plate on the engine side. Same for the Euro throttle house, it also has both ports, but the US port is here blinded off. Looks like Mercedes just made one house with both ports physically there, but blinded off one of them depending on the market (US/Euro). Have you seen this too?
Back to timing: Just for me to get on the same page as you guys, because I think I may have misunderstood how to read BTDC and ATDC using the scope. Up to now, I thought that, when I increase the rpms, and looking at the degrees on the scale using the scope, I see the degrees increase on the scale, and I though this was + degrees in the ATDC regime, and when degrees went in the other direction and down below zero, I would be in the BTDC regime, like _after_ zero (ADTC) and _before_ zero (BTDC). Am I wrong here, so that it is actually opposite??

The timing degrees in the picture from the service manual above is actually for a euro 280SL with an 051 distributor, thus without the emission control system. As you see, it says 3 degrees +/- 1 degree ATDC at idle.
For the US emission control version with US throttle house config and an 062 distributor, which my manual 280SL had, before I replaced it with the 123ignition, see the similar idle speed timing below, where it says 8 degrees ATDC!
What do you think?
Thanks,
Christian