If your 280 engine has a Starting solenoid on the back of the injector pump (late 280SL injector pump doesn't have one), make sure it operates. This solenoid moves the rack into a rich position, which aids in starting. Mine wasn't working until recently due to the relay requiring cleaning. I noticed an improvement immediately when starting the car warm (or at full operating temperature).
If you are unfamiliar with testing the Starting solenoid, ask and more details will be provided. This, of course, is only one possible cause of many! Good luck.
Best Regards,
J. P. Mose
1968 250SL